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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9744 | MP07-66 | Phosphatase | |
MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells. | |||
TN1507 | Clematichinenoside AR | TNF , Autophagy | |
Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associated with collagen-induced arthritis. | |||
T5S1285 | (+)-(3R,8S)-Falcarindiol | Falcarindiol | Others |
1. (+)-(3R,8S)-Falcarindiol is a potential new anticancer agent that exerts its activity through inducing ER stress and apoptosis. 2. Falcarindiol induces immunosuppressive effects in vitro and in vivo and might be a nov... | |||
T20168 | Aurothiomalate sodium | Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate | Others , PKC |
Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium (Miochrysin) is a potent and selective inhibitor of oncogenic PKC-ι signaling. Aurothiomalate ... | |||
T2996 | Tetrandrine | NSC-77037,d-Tetrandrine,Hanfangchin A,Fanchinine,Sinomenine A | Potassium Channel , Calcium Channel |
Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the c... | |||
T41303 | Isoflupredone | Delta-Fluorocortisone,Isoflupredona,Isoflupredonum,9-Fluoroprednisolone | Others |
Isoflupredone (Isoflupredonum) is a synthetic corticosteroid that acts in vivo by binding to glucocorticoid and corticosteroid receptors in animals (such as horses) to inhibit inflammatory cells and inhibit the expressio... | |||
T6S2140 | β-Anhydroicaritin | Anhydroicaritin,Beta-Anhydroicaritin | MMP , Others , TNF , Interleukin |
1. β-Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. β-Anhydroicaritin phytosomes can inhibit enhanced bone turnover induced by ovariectomy, improve BMD the biomechanical ... | |||
T5S2357 | Acetylcorynoline | (+)-Corynoline Acetate,O-Acetylcorynoline | Antifungal |
1. Acetylcorynoline (O-Acetylcorynoline) has antifungal、anti-inflammatory activity. 2. Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of dendritic cells maturation and function. 3... | |||
T2548 | Diflorasone | Glucocorticoid Receptor | |
Diflorasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorti... | |||
T34952 | Trinactin | Akd1D,Akd 1D,Akd-1D | |
Trinactin is a nonactin homolog that has Immunosuppressive effects. | |||
T30136 | Armepavine hydrochloride, (+/-)- | DL-Armepavine hydrochloride | |
Armepavine hydrochloride, (+/-)- is a compound which has been shown to exert immunosuppressive effects on T lymphocytes and on lupus nephritic mice. | |||
T33883 | Paramethasone Acetate | NCGC00185748-01,Monocortin,CHEBI:31963,8X50N88ZDP,UNII-8X50N88ZDP | Others |
Paramethasone Acetate is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive effects that can be used in the treatment of systemic lupus erythematosus. | |||
TN4841 | Ptaquiloside | ||
Ptaquiloside shows genotoxicity, it also has carcinogenic effects. Ptaquiloside has immunosuppressive effects, it reduces NK cell activities by enhancing metallothionein expression, which is prevented by selenium. | |||
T61099 | Mycophenolic acid sodium | ||
Mycophenolic acid sodium is a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH), exhibiting an EC50 of 0.24 μM. It has broad antiviral activity against RNA viruses, including influenza. Additi... | |||
T13734 | ILS-920 | Others | |
ILS-920 is a Rapamycin analog characterized by diminished immunosuppressive effects but remarkable neuroprotective properties. It exhibits selective binding affinity towards the immunophilin FKBP52 as well as the β1-subu... | |||
T82142 | Hymenistatin I | ||
Hymenistatin I, a cyclic octapeptide [c-(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-Ile-Ile-)], exhibits immunosuppressive effects on both humoral and cellular immune responses [1]. | |||
T11701 | J22352 | Caspase | |
J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in glioblastoma by promoting HDAC6 degradation. It does so by inhibiti... | |||
T61090 | CD73-IN-8 | ||
CD73-IN-8, a potent CD73 inhibitor, prevents the catalytic activity of CD73, an enzyme responsible for converting extracellular 5'-phosphate adenosine (5'-AMP) to adenosine. Adenosine, once produced, can induce immunosup... | |||
T78304 | Bapotulimab | BAY-1905254 | |
Bapotulimab (BAY-1905254) is a fully human IgG2 antibody that targets the immunoglobulin-like domain-containing receptor 2 (ILDR2), exhibiting antitumor and immunosuppressive effects [1]. | |||
T63856 | M1069 | ||
M1069 is a selective, orally active A2A/A2B diadenosine receptor antagonist that is more than 100-fold more selective than subtypes A1 and A3. M1069 antagonizes the immunosuppressive mechanisms induced by adenosine and e... |